Professor of Cell Biology

Manager of Functional Chemical Genomics Core Facility

Pujiang Scholar

Contact Information
Haixia Institute of Science and Technology(HIST)
Fujian Agriculture and Forestry University (FAFU)

15 Shangxiadian Road

Fuzhou, Fujian 350002, P. R. China

Email: xiaoyuezhu@fafu.edu.cn

Education
2002-2005, Ph.D., University of Michigan - Ann Arbor, Michigan, US

2000-2002, M.S., University of Michigan - Ann Arbor, Michigan, US

1996-2000, B.S., Nankai University, Tianjin, China

Professional Experience

2016-present, Professor, Fujian Agriculture and Forestry University, China

2013-2016, Associate Professor, Donghua University, China

2006-2013, Senior Engineer, Incept BioSystems, Inc., US

2005-2006, Postdoctoral fellow,  University of Michigan - Ann Arbor, Michigan, US

Research Interests

By integrating microfluidic devices with state-of-the-art technologies to apply mechanical, topological and biochemical stimulations on cells or tissues, I am interested in developing novel tools and platforms for plant and mammalian cell biology studies, which will be critical for understanding the mechanisms of growth and development of horticulture plants at the tissue, cellular and molecular levels.

Publications

Xu TG, Wu L, Wang XF, Zhu XY, Chen JZ, Yao FL, Zhou HB, Li XX*. A seal-free valveless digital PCR chip supported with a high-pressure water circulation system. Proceedings IEEE Micro Electro Mechanical Systems, 2020, 1079-1082 (Proceedings paper, 2020 33^rd IEEE International Conference on Micro Electro Mechanical Systems)

Xu TG, Wu L, Wang XF, Zhu XY, Bao YG, Cai SR, Li G, Li XX*. A PDMS-Based Digital PCR Chip with Vacuum Aspiration and Water-filling Cavity Integrated for Sample Loading and Evaporation Reduction. Proceedings IEEE Micro Electro Mechanical Systems, 2018, 1142-1145 (Proceedings paper, 2018 IEEE Micro Electro Mechanical Systems)

Wu L, Xu TG, Li G, Zhu XY, Zhao JL*. A Facile Alignment of PDMS Layers for the Fabrication of 3D Microfluidic Devices Using Synergistic Zipper. Proceedings IEEE Micro Electro Mechanical Systems 2018, 1265-1268 (Proceedings paper, 2018 IEEE Micro Electro Mechanical Systems)

Wang MY, Xiao YC, Lin LZ, Zhu XY, Du LF, Shi XY*. A microfluidic chip integrated with hyaluronic acid-functionalized electrospun chitosan nanofibers for specific capture and nondestructive release of CD44-overexpressing circulating Tumor Cells. Bioconjugate Chemistry, 2018, 1081-1090 DOI: 10.1021/acs.bioconjchem.7b00747

Xu GW, Tan YL, Xu TG, Yin D, Wang MY, Shen MW, Chen XF*, Shi XY*, Zhu XY*. Hyaluronic acid-functionalized electrospun PLGA nanofibers embedded in a microfluidic chip for cancer cell capture and culture. Biomaterial Sciences, 2017, 5, 752-761

Yin D, Xu GW, Wang MY, Shen MW, Xu TG, Zhu XY*, Shi XY*. Effective cell trapping using PDMS microspheres in an acoustofluidic chip. Colloids Surf., B 2017, 157, 347-354

Kim SJ, Zhu XY, Takayama S. Gravity-driven fluid pumping and cell manipulation. Microtechnology for Cell Manipulation and Sorting, Springer science + business media, 2017, 175-192

Fan ZY, Zhao YL, Zhu XY*, Luo Y, Shen MW, Shi XY*. Folic acid-modified electrospun polyvinyl alcohol/polyethyleneimine nanofibers for cancer cell capture applications. Chin. J. Polym. Sci. 2016, 34, 755 - 765. doi:10.1007/s10118-016-1792-6

Zhou BQ, Yang J, Peng C, Zhu JZ, Tang YQ, Zhu XY, Shen MW, Zhang GX*, Shi XY*. PEGylated polyethylenimine-entrapped gold nanoparticles modified with folic acid for targeted tumor CT imaging. Colloids and Surfaces B. Biointerfaces, 2016:140:489-496. DOI: 10.1016/j.colsurfb.2016.01.019

Li D, Zhang YX, Wen SH, Song Y, Tang YQ, Zhu XY, Shen MW, Mignani S, Majoral JP, Zhao QH*, Shi XY*. Construction of polydopamine-coated gold nanostars for CT imaging and enhanced photothermal therapy of tumors: an innovative theranostic strategy. J. Mater. Chem. B 2016, 4, 4216 -4226

Chen C, Zhou BQ, Zhu XY, Shen MW, Shi XY*. Branched polyethyleneimine modified with hyaluronic acid via a PEG spacer for targeted anticancer drug delivery. RSC Adv. 2016, 6, 9232 - 9239

Zhao YL, Zhu XY, Liu H, Luo Y, Wang SG, Shen MW, Zhu MF, Shi XY*. Dendrimer-functionalized electrospun cellulose acetate nanofibers for targeted cancer cell capture applications. J. Mater. Chem. B 2014, 2, 7384–7393.

Moracs C, Kim BC, Zhu XY, Mills K, Dixon AR, Thouless MD, Takayama S*, Defined topologically-complex protein matrices to manipulate cell shape via three-dimensional fiber-like patterns, Lab-on-a-chip, DOI:10.1039/C4LC00122B, 2014

Mills KL, Zhu XY, Takayama S, Thouless MD*, The mechanical properties of a surfacemodified layer on poly(dimethylsiloxane), Journal of Materials Research, 2008,23: 37-48

Huh D, Mills KL, Zhu XY, Burns MA, Thouless MD, Takayama S*, Reconfigurable elastic nanochannels for tunable nanofluidic manipulation, Nature Materials, 2007,6: 424-428

Lam MT, Sim S, Zhu XY, Takayama S*, The effect of continuous wavy micropatterns on silicone substrates on the alignment of skeletal muscle myoblasts and myotubes. Biomaterials, 2006,27: 4340-4347

Chung Y, Zhu XY, Gu W, Smith GD, Takayama S*, Microscale integrated sperm sorter. Methods in Molecular Biology, 2006,321: 227-244

Suh RS, Zhu XY, Phadke N, Ohl DA, Takayama S, Smith GD*, In vitro fertilization within microfluidic channels requires lower total numbers and lower concentrations of spermatozoa. Human Reproduction, 2006,21: 477-483

Zhu XY, Mills KL, Peters PR, Bahng JH, Liu E, Shim J, Naruse K, Csete ME, Thouless MD, Takayama S*, Fabrication of reconfigurable protein matrices by cracking. Nature Materials, 2005,4: 403-406 (Also featured as a Cover Article)

Zhu XY, Bersano-Begey TF, Kamotani Y, Takayama S*, Microbioreactor, The Wiley Encyclopedia of Medical Instruments and Devices. 2nd ed. Wiley, 2005

Zhu XY, Bersano-begey TF, Takayama S*, Nanomaterials for engineering cells, In: Nalwa HS, editor. Encyclopedia of Nanoscience and Nanotechnology, American Scientific Publisher, 2004, 857

Zhu XY, Chu LY, Chueh BH, Shen MW, Hazarika B, Phadke N, Takayama S*, Arrays of horizontallyoriented mini-reservoirs generate steady microfluidic flows for continuous perfusion cell culture and gradient generation, Analyst, 2004, 129:1026-1031

Gu W, Zhu XY, Futai N, Cho BS, Takayama S*, Computerized microfluidic cell culture using elastomeric channels and Braille displays, Proceedings of the National Academy of Sciences of the United States of America (PNAS), 2004,101: 15861-15866

Shim J, Bersano-Begey TF, Zhu XY, Tkaczyk AH, Linderman J, Takayama S*, Micro- and nanotechnologies for studying cellular function, Current Topics in Medicinal Chemistry, 2003,3: 687

Cho BS, Schuster TG, Zhu XY, Chang D, Smith GD, Takayama S*, Passively-driven integrated microfluidic system for separation of motile sperm, Analytical Chemistry, 2003,75: 1671-1675