Professor of Metabolomics

Manager of Metabolomics Core Facility

Contact Information

Haixia Institute of Science and Technology (HIST)
Fujian Agriculture and Forestry University (FAFU)

15 Shang Xia Dian Road

Fuzhou, Fujian 350002, P. R. China

Phone: 86-591-86391591

Email: xmyu0616@fafu.edu.cn

Education

2007.8-2014.6 Ph.D., University of Illinois, Urbana-Champaign

2004-2007, M.S.,  Fujian Agriculture and Forestry University, China

2000-2004, B.S., Fujian Agriculture and Forestry University, China

Professional Experience

2020-Present, Professor, Fujian Agriculture and Forestry University, China

2014-2020, Associate Professor, Fujian Agriculture and Forestry University, China

Research Interests

Our research interest focuses on deciphering the synthesis and regulation of microbial or plant-derived small-molecule natural products and understanding how plant-microbiome interactions shape plant-associated microbiota and affect plant health. In this regard, major research topics include:

1. Functional characterization of interactions between plant microbiota (especially actinomycetes) and host plants
2. Discovery of bioactive natural products from plant-derived actinomycetes
3. Plant specialized metabolism and regulation using tea plants (Camellia sinensis) as a model organism

Publications (#co-first author, *co-corresponding author)

Yu, X.^#, Xiao, J.^#, Chen, S.^#, Yu, Y., Ma, J., Lin, Y., Li, R., Lin, J., Fu, Z., Zhou, Q., Chao, Q., Chen, L.*, Yang, Z.*, & Liu, R*. (2020). Metabolite signatures of diverse Camellia sinensis tea populations. Nature Communications, 11(1), 5586. DOI: 10.1038/s41467-020-19441-1.

Wang, Z.; Zeng, Y.; Wu, X.; Li, Z.; Tao, Y.; Yu, X.; Huang, Z.*; Chen, F.*, Access to chiral -substituted--hydroxy arylphosphonates enabled by biocatalytic dynamic reductive kinetic resolution. Organic & Biomolecular Chemistry 2020, 18(14): 2672-2677. DOI: 10.1039/d0ob00379d.

Zhao, X.^#; Chen, S.^#; Wang, S.; Wang, X.; Lin, Y.; Su, F.; Yang, Z.*; Yu, X.*, Defensive responses of tea plants (Camellia sinensis) against tea green leafhopper attack: A multi-omics study. Frontiers in Plant Science 2020, 10 (1705). DOI: 10.3389/fpls.2019.01705.

Chen, S.#; Liu, H.#; Zhao, X.; Li, X.; Shan, W.; Wang, X.; Wang, S.; Yu, W.; Yang, Z.*; Yu, X.*, Non-targeted metabolomics analysis reveals dynamic changes of volatile and non-volatile metabolites during oolong tea manufacture. Food Research International 2020. DOI: 10.1016/j.foodres.2019.108778.

Li, X.; Smid, S. D.; Lin, J.; Gong, Z.; Chen, S.; You, F.; Zhang, Y.; Hao, Z.; Lin, H.; Yu, X.*; Jin, X.*, Neuroprotective and anti-amyloid β effect and main chemical profiles of white tea: Comparison against green, oolong and black tea. Molecules 2019, 24(10), 1926. DOI: 10.3390/molecules24101926

Liao, X.; Li, M.; Liu, B.; Yan, M.; Yu, X.; Zi, H.; Liu, R.; Yamamuro, C., Interlinked regulatory loops of ABA catabolism and biosynthesis coordinate fruit growth and ripening in woodland strawberry. Proceedings of the National Academy of Sciences of the United States of America, 2018, 115, E11542-E11550.

Shan, W.^#; Zhou, Y.^#; Liu, H.; Yu, X., Endophytic actinomycetes from tea plants (Camellia sinensis): Isolation, abundance, antimicrobial, and plant-growth-promoting activities. Biomed Research International 2018, 1470305. DOI: 10.1155/2018/1470305.

Chen, S.^#; Lin, J.^#; Liu, H.; Gong, Z.; Wang, X.; Li, M.; Aharoni, A.; Yang, Z.; Yu, X., Insights into tissue-specific specialized metabolism in Tieguanyin tea cultivar by untargeted metabolomics. Molecules 2018, 23(7), 1817. DOI: 10.3390/molecules23071817.

Chen, S.; Li, M.; Zheng, G.; Wang, T.; Lin, J.; Wang, S.; Wang, X.; Chao, Q.; Cao, S.; Yang, Z.; Yu, X., Metabolite profiling of 14 Wuyi Rock tea cultivars using UPLC-QTOF MS and UPLC-QqQ MS combined with chemometrics. Molecules 2018, 23(2), 104. DOI: 10.3390/molecules23020104.

Yang, N.; Jiang, J.; Xie, H.; Bai, M.; Xu, Q.; Wang, X.; Yu, X.; Chen, Z.; Guan, Y., Metabolomics reveals distinct carbon and nitrogen metabolic responses to magnesium deficiency in leaves and roots of soybean [Glycine max (Linn.) Merr.]. Frontiers in Plant Science 2017, 8 (2091). DOI: 10.3389/fpls.2017.02091.

Shan, W.; Liu, H.; Zhou, Y.; Yu, X., Draft genome sequence of Streptomyces sp. XY006, an endophyte isolated from tea (Camellia sinensis). Genome Announcements 2017, 5, e00971-17. DOI: 10.1128/genomeA.00971-17.

Liu, H.; Shan, W.; Zhou, Y.; Yu, X., Draft genome sequence of Paenibacillus sp. XY044, a potential plant growth promoter isolated from a tea plant. 2017. Genome Announcements 2017, 5, e01016-17. DOI: 10.1128/genomeA.01016-17. 

Zhang, Q.; Cai, M.; Yu, X.; Wang, L.; Guo, C.; Ming, R.; Zhang, J., Transcriptome dynamics of Camellia sinensis in response to continuous salinity and drought stress. 2017. Tree Genetics & Genomes 2017, 13, 78. DOI: 10.1007/s11295-017-1161-9.

Blodgett, J. A.; Zhang, J. K.; Yu, X.; Metcalf, W. W., Conserved biosynthetic pathways for phosalacine, bialaphos and newly discovered phosphonic acid natural products. Journal of Antibiotics 2016, 69, 15-25. DOI:10.1038/ja.2015.77.

Huang, T.; Yu, X.; Gelbic, I.; Guan, X., RAP-PCR fingerprinting reveals time-dependent expression of development-related genes following differentiation process of Bacillus thuringiensis. Canadian Journal of Microbiology 2015, 61, 683-90. DOI: 10.1139/cjm-2015-0212.

Yu, X.; Price, N. P.; Evans, B. S.; Metcalf, W. W., Purification and characterization of phosphonoglycans from Glycomyces sp. strain NRRL B-16210 and Stackebrandtia nassauensis NRRL B-16338. Journal of Bacteriology 2014, 196, 1768-79. DOI: 10.1128/JB.00036-14.

Gao, J.; Ju, K. S.; Yu, X.; Velasquez, J. E.; Mukherjee, S.; Lee, J.; Zhao, C.; Evans, B. S.; Doroghazi, J. R.; Metcalf, W. W.; van der Donk, W. A., Use of a phosphonate methyltransferase in the identification of the fosfazinomycin biosynthetic gene cluster. Angewandte Chemie International Edition 2014, 53, 1334-7. DOI: 10.1002/anie.201308363.

Cioni, J. P.; Doroghazi, J. R.; Ju, K. S.; Yu, X.; Evans, B. S.; Lee, J.; Metcalf, W. W., Cyanohydrin phosphonate natural product from Streptomyces regensis. Journal of Natural Product 2014, 77, 243-9. DOI: 10.1021/np400722m.

Yu, X.; Doroghazi, J. R.; Janga, S. C.; Zhang, J. K.; Circello, B.; Griffin, B. M.; Labeda, D. P.; Metcalf, W. W., Diversity and abundance of phosphonate biosynthetic genes in nature. Proceedings of the National Academy of Sciences of the United States of America, 2013, 110, 20759-64. DOI: 10.1073/pnas.1315107110.

Yu, X.; Huang, T.; Huang, Z.; Powell, C. A.; Guan, X., Expression and characterization of inhA gene from Bacillus thuringiensis 8010. World Journal of Microbiology and Biotechnology 2007, 23, 1621-1625. DOI: 10.1007/s11274-007-9408-5.