Fangjie Zhu
Professor of Developmental Biology
Contact Information
Haixia Institute of Science and Technology
Fujian Agriculture and Forestry University
No.15 Shangxiadian Road, Cangshan District
Fuzhou 350028, China
Email: fjzhu@fafu.edu.cn
Transisbio：http://hbmcsysbio.team or http://camds.fafu.edu.cn:8080/
Education
2010–2013, Ph.D., The University of Tokyo, Japan
2007–2010, M.S., Tsinghua University, China
2003–2007, B.S., M.Sc, Tsinghua University, China
Professional Experience
2020–Present, HIST, Professor, Fujian Agriculture and Forestry University, China
2018–2020, Research Associate, University of Cambridge, Britain
2014–2018, Postdoc, Karolinska Institute, Sweden
Research Interests
Our primary interests are to elucidate the mechanisms underlying transcriptional regulation in plants by combining supramolecular chemistry, epigenetics, and bioinformatics approaches and by applying novel sequencing-based high-throughput technologies. In particular, we are interested in transcriptional regulation that occurs during plant regeneration.
Publications
F. Zhu, L. Farnung, E. Kaasinen, B. Sahu, Y. Yin, Bei. Wei, S.O. Dodonova, K.R. Nitta, E. Morgunova, M. Taipale, P. Cramer, J. Taipale, The interaction landscape between transcription factors and the nucleosome. Nature, 2018, 562, p76.
F. Zhu, T. Nishimura and T. Kato, Organic/inorganic fusion materials: cyclodextrin-based polymer/CaCO3 hybrids incorporating dye molecules through host-guest interactions. Polym. J., 2015, 47, p122.
F. Zhu, T. Nishimura, H. Eimura, and T. Kato, Supramolecular effects on formation of CaCO3 thin films on a polymer matrix. CrystEngComm, 2014, 16, p1496.
F. Zhu, T. Nishimura, T. Sakamoto, H. Tomono, H. Nada, Y. Okumura, H. Kikuchi, and T. Kato, Tuning the stability of CaCO3 crystals with magnesium ions for formation of aragonite thin films on organic polymer templates. Chem. Asian J., 2013, 8, p3232.
F. Zhu, Y. Kong, J. Liang, C. Li, Y. Hu, Y. Zhou, X. Liu, L. Xie, and R. Zhang, Tuning calcite magnesium content by soluble shell matrices: Insights into biomineral impurity control. Mater. Sci. Eng. C, 2010, 30, p963.
A. Jolma, J. Zhang, E. Mondragon, E. Morgunova, T. Kivioja, K.U. Laverty, Y. Yin, F. Zhu, G. Bourenkov, Q. Morris, T.R. Hughes, L.J.III Maher, J. Taipale, Binding specificities of human RNA-binding proteins toward structured and linear RNA sequences. Genome Res 2020, 30, p962.
S.O. Dodonova, F. Zhu, C. Dienemann, J. Taipale, P. Cramer, Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function. Nature 2020, 580, p669.
B. Wei, A. Jolma, B. Sahu, L.M. Orre, F. Zhong, F. Zhu, T. Kivioja, I. Sur, J. Lehtio, M. Taipale, J. Taipale, A protein activity assay to measure global transcription factor activity reveals determinants of chromatin accessibility. Nat. Biotechnol. 2018, 36, p521.
E. Morgunova, Y. Yin, P.K. Das, A. Jolma, F. Zhu, A. Popov, Y. Xu, L. Nilsson, J. Taipale, Two distinct DNA sequences recognized by transcription factors represent enthalpy and entropy optima. Elife 2018, 7.
J. Su, F. Zhu, G. Zhang, H. Wang, L. Xie and R. Zhang, Transformation of amorphous calcium carbonate nanoparticles into aragonite controlled by ACCBP. CrystEngComm, 2016, 18, p2125.
T. Nishimura, F. Zhu, H. Tomono, H. Nada, T. Kato, バイオミネラリゼーションに学ぶ有機／無機複合体の設計と合成：高分子およびマグネシウムイオンによる炭酸カルシウムのモルホロジー制御, オレオサイエンス, 2014, 14, p417.
H. Tomono, H. Nada, F. Zhu, T. Sakamoto, T. Nishimura, and T. Kato, Effects of magnesium ions and water molecules on the structure of amorphous calcium carbonate: a molecular dynamics study. J. Phys. Chem. B, 2013, 117, p14849.
Y. Lin, W. Zhang, F. Zhu, J. Su, D. Fang, Y. Yang, G. Zhang, L. Xie, R. Zhang, and H. Wang, Subcellular localization of N-deoxyribosyltransferase in Lactobacillus fermentum: cell surface association of an intracellular nucleotide metabolic enzyme. FEMS Microbiol. Lett., 2011, 323, p132.
L. Xie, F. Zhu, Y. Zhou, C. Yang, and R. Zhang, Molecular approaches to understand biomineralization of shell nacreous layer. Prog. Mol. Subcell. Biol., 2011, 52, p331.
Y. Zhou, Z. He, C. Li, L. Xiang, F. Zhu, G. Zhang, L. Xie, and R. Zhang, Correlations among mRNA expression levels of Engrailed, BMP2 and Smad3 in mantle cells of pearl oyster Pinctada fucata. Prog. Biochem. Biophys., 2010, 37, p737.
C. Li, J. Huang, S. Li, W. Fan, Y. Hu, Q. Wang, F. Zhu, L. Xie, and R. Zhang, Cloning, characterization and immunolocalization of two subunits of calcineurin from pearl oyster (Pinctada fucata). Comp. Biochem. Physiol. B: Biochem. Mol. Biol., 2009, 153, p43.
Y. Kong, G. Jing, Z. Yan, C. Li, N. Gong, F. Zhu, D. Li, Y. Zhang, G. Zheng, H. Wang, L. Xie, and R. Zhang, Cloning and characterization of Prisilkin-39, a novel matrix protein serving a dual role in the prismatic layer formation from the oyster pinctada fucata. J. Biol. Chem., 2009, 284, p10841.